Overwhelming fatigue; pins and needles; numbness or dead spots on hands/arms or feet; twitches or loss of power in limbs (especially if one-sided rather than symmetrical). Ringing in the ears; eye twitching (nystagmus) or unable to focus. Persistent cough.
They are all conditions connected with the peripheral nervous system (PNS).
The PNS has two parts - sensory and motor. The sensory part lets you feel things - if you hold something in your hand then nerve endings on the palm of your hand send signals up your arm, up your spine, to your brain which your brain can interpret (each joint in your fingers also sends a signal to say what angle it’s at, the muscles in your forearm say how stretched they are and how hard they’re working, and so on).
The motor part lets you do things. Your brain sends a signal to each individual muscle, for the muscles that operate your hand, to tell them how much to pull or relax (muscles can’t push) to get the perfect grip on the thing you’re holding (or the piano you are playing).
The rest of the nervous system is the central nervous system (CNS), which is essentially the brain and spine. Your ear and eye, even though they’re inside your skull, are actually part of the PNS because they aren’t “brain” (ear served by vestibulocochlear nerve = Cranial VIII; eye served by optic (I) for sensory, and oculomotor (III), trochlear (IV) and abducen (VI)).
B12 is vital for manufacturing cell membranes - without B12 the membrane can form badly. Nerves have a lot of cell membrane - the Schwann cell which surrounds each axon (the part of the nerve cell that transmits the signal) is essentially tens or hundreds of layers of cell membrane as insulation. Just like the wires in a mobile phone, if they aren’t insulated from each other then the nerve doesn’t work.
It either does nothing (signal doesn’t get through), or sends a signal when it’s not supposed to (picks up a signal from a nearby axon and sends that on by mistake).
So when you feel pins and needles, it could be because the nerves that serve your skin are picking up signals from other nerves on the way up your arm, or in your neck. Your stretch receptors are trying to say “20% stretch” which is an “on” signal on the nerve that detects 20% stretch. But the “on” signal jumps across to a skin nerve cell (it might go up both). So your brain gets a signal from a skin nerve cell, and assumes there’s pain on the skin at that point. The stretch signal keeps jumping onto different skin nerve cells (they’re all in a bundle of nerve axons together), and you get the pins-and-needles effect. Whereas if the “on” signal jumps to a motor nerve axon, it may cause a muscle to twitch which makes your arm or leg or finger twitch and you can’t control it.
Alternatively the “on” signal going from the skin nerve cell may not get through at all. You get a numb patch - even if you stick a pin in you can’t feel it! Or if it’s a motor nerve that can’t get through, you could have weakness (eg foot drop) or paralysis of one or a few muscles.
You can have the same effect in one of the cranial nerves, making you see dark patches
It isn’t always B12 deficiency, but it might be if you can’t find another cause. It’s the same. For a motor nerve, it either causes twitching (eg eye movements, funny focus) or you can’t make a muscle move (similar to lazy eye). For sensory nerves you might get flashing lights or dark patches, or tinnitis. And the persistent dry cough could be if a throat surface nerve keeps sending a “something stuck here” signal to the brain.
Yes. Lack of B12 means that the cell membrane can’t form properly (it shows up on the nerves because they have so many layers of membrane). But supplementing with B12 lets the nerves repair themselves. Don’t expect instant results, but expect some things to get better over time.
Julia found her eyesight going as her eyes refused to focus on the same things as each other. She's been for all sorts of tests and treatment, but now that she's on B12 replacement therapy she's starting to see an improvement.
Dr Chandy was nominated for the North East Local Heroes award. The interviewer was at first surprised - people don't get awards for doing what they are paid to do - but she persisted.
Susan gets very tired, which isn't much fun especially as she has so much to do. Here she tells her story.
Janette first appeared in the BBC InsideOut documentary in October 2006. Since then the NHS has forced her doctor to withdraw B12 replacement therapy on a number of occasions, and she tells of her struggles with having B12 and then having it taken away.
She has bravely agreed to be filmed without her usual wig, but her memory is playing up because it is so long since her last injection.
Donna, like so many women, wants to live a normal life. Vitamin B12 could give her that chance.
Frankie tells of how she suffered, the tests she had to endure until doctors worked out what was wrong, and what a difference it has made.
The local MP (Grahame Morris MP for Easington - who was a BMS (BioMedical Scientist) in the labs at Sunderland Royal Infirmary) interviews people with B12 deficiency to hear their story (August 27 2010). Here Jane describes the symptoms, and how she can't wait for her next B12 injection (in fact, she knows that she needs injections every 2 weeks because she's keeping a diary of the symptoms). We're restricted how often the GP can give injections, which is why we want to raise awareness.
New documentary out from Elissa Leonard in North America, featuring Sally Pacholok and many other internationally renowned experts.
June describes her suffering when doctors didn't follow the standard protocol after any stomach or intestinal operation - to offer B12 replacement therapy
The Scottish Parliament discusses Pernicious Anaemia and vitamin B12 deficiency on Wednesday 7 March 2012.
This video is over 1 hour long and represents real political change - we are at last on our way.